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Menaquinone-7 (MK-7) Is A Type Of Vitamin K2

Menaquinone-7 (MK-7) is a type of vitamin K2, which is a fat-soluble vitamin essential for various physiological functions in the body. MK-7 is produced by gut bacteria and is also present in certain fermented foods. Below are some key points about menaquinone-7:

1. Bone Health: Vitamin K2, including MK-7, plays a crucial role in bone metabolism by aiding the incorporation of calcium into bone tissue. Sufficient vitamin K2 intake is linked to improved bone mineral density and a reduced risk of fractures, particularly in postmenopausal women and elderly individuals.

2. Cardiovascular Health: Vitamin K2 may have protective effects on cardiovascular health by preventing artery calcification and reducing the risk of atherosclerosis. MK-7, in particular, has been shown to direct calcium away from arterial walls and into bone tissue, possibly reducing the risk of arterial stiffness and cardiovascular events.

3. Regulation of Calcium: MK-7 is involved in calcium metabolism regulation in the body. It helps activate proteins such as osteocalcin and matrix Gla protein (MGP), which are essential for bone mineralization and the prevention of soft tissue calcification, respectively.

4. Brain Health: Emerging research suggests that vitamin K2, including MK-7, may play a role in brain health and cognitive function. Some studies have found links between higher vitamin K2 intake and better cognitive performance, although more research is required to fully understand the mechanisms involved.

5. Anti-inflammatory Effects: Vitamin K2, including MK-7, may have anti-inflammatory effects that contribute to its overall health benefits. Chronic inflammation is linked to various chronic diseases, including osteoporosis, cardiovascular disease, and neurodegenerative disorders.

6. Dietary Sources: MK-7 is present in particular fermented foods, mostly natto, which is a traditional Japanese dish made from fermented soybeans. It can also be obtained through supplementation. MK-7 supplements are often derived from fermented soybeans or other natural sources.

7. Absorption and Bioavailability: MK-7 has a longer half-life in the body compared to other forms of vitamin K2, such as menaquinone-4 (MK-4). This prolonged half-life may contribute to its greater bioavailability and effectiveness in promoting bone and cardiovascular health.

Overall, menaquinone-7 (MK-7) is a form of vitamin K2 with crucial roles in bone metabolism, cardiovascular health, and potentially other physiological processes. Including MK-7-rich foods in the diet or taking supplements may help support overall health and reduce the risk of certain chronic diseases.

Sato T, Inaba N, Yamashita T. MK-7 and Its Effects on Bone Quality and Strength. Nutrients. 2020 Mar 31;12(4):965. doi: 10.3390/nu12040965. PMID: 32244313; PMCID: PMC7230802.

Merra G, Dominici F, Gualtieri P, Capacci A, Cenname G, Esposito E, Dri M, Di Renzo L, Marchetti M. Role of vitamin K2 in bone-vascular crosstalk. Int J Vitam Nutr Res. 2022 Aug 30. doi: 10.1024/0300-9831/a000761. Epub ahead of print. PMID: 36039403. Jadhav N, Ajgaonkar S, Saha P, Gurav P, Pandey A, Basudkar V, Gada Y, Panda S, Jadhav S, Mehta D, Nair S. Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Front Pharmacol. 2022 Jun 14;13:896920. doi: 10.3389/fphar.2022.896920. PMID: 35774605; PMCID: PMC9237441.

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